Similarly, upregulation of DR5 has been associated with chemosensitisation of myeloma cells to TRAIL-induced apoptosis following treatment with doxorubicin, As2O3, the histone deacetylase inhibitor Trichostatin A, or the Akt inhibitor perifosine (Jazirehi et al, 2001; Liu et al, 2003; Fandy and Srivastava, 2006; David et al, 2008). Here, AKT1 is linked to plasma cell myeloma.