CASP8 and B-cell chronic lymphocytic leukemia: We have previously reported that PBOX-6-induced apoptosis may involve both caspase-dependent and -independent pathways (Zisterer et al, 2000; McGee et al, 2001), and have recently demonstrated PBOX-15-induced apoptosis of CLL cells to be caspase-8 dependent (McElligott et al, 2009).