INS and obesity due to melanocortin 4 receptor deficiency: Although the effects of obesity and high insulin as promoters of cancer cell proliferation are described for colon (Giovannucci, 2001), breast (Vona-Davis et al, 2007), endometrium and kidney (Hjartaker et al, 2008), little is known about the altered gene signatures with regard to cellular features like cell adhesion and migration.