SLC2A1 and neoplasm: Additionally, aggressively growing tumours are often characterized by an increased expression of GLUT-1 glucose transporters (Hauptmann et al, 2005), resulting in a high glucose uptake, a metabolic shift to anaerobe glycolysis and therefore an increased lactate production (Gillies and Gatenby, 2007; Kroemer and Pouyssegur, 2008).