Chemokines that are found in the tumour environment, produced mainly by activated macrophages, are the CXCR3 ligands CXCL9/MIG and CXCL10/IP-10, attracting CXCR3-expressing T-cells and natural killer cells (Loetscher et al, 1996; Kunz et al, 1999; Romagnani et al, 2001a, 2001b; Payne and Cornelius, 2002). This evidence concerns the gene CXCL9 and neoplasm.