Although the chemokines CXCL9, CXCL10 and CXCL11 were reported to have an angiostatic effect when expressed by melanoma cells (Romagnani et al, 2001a, 2001b; Mehrad et al, 2007; Keeley et al, 2008), our study suggests that the chemokine CXCL9 may promote additional metastasis, when it is expressed in TuECs, by means of increasing transendothelial and melanoma migration. The gene discussed is CXCL10; the disease is melanoma.