Therefore, to establish a basis for further studies on the mechanism of ALDH1 in ovarian cancer, we examined ALDH1 expression and localization in normal ovary and ovarian tumors in order to determine if ALDH1 expression is altered, if the cell types expressing ALDH1 changes and if ALDH1 expression in benign tumors resembles normal ovary or malignant tumors. This evidence concerns the gene ALDH1A1 and ovarian cancer.