However, in sharp contrast to wild-type flies, Ecc15 infection did not increase the number of mitotic cells (PH3-positive; Figure 3d) or change the pattern and distribution of escargot-GFP-positive cells (Figure 3c) in the gut of flies with reduced EGFR signaling in ISCs, indicating a lack of induction of epithelium renewal. This evidence concerns the gene EGFR and infection.