rs738409 is a missense variation (I148M) in PNPLA3. Triglyceride lipase activity of mutant PNPLA3 (I148M) was completely abolished; this led to increased triglyceride accumulation in the human hepatoma cells, which exhibited more and larger lipid droplets [37]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.