MMP14 and neoplasm: In the past decade, it has been established that the matrix metalloproteinases (MMPs), including Membrane-type-1 MMP (MT1-MMP or MMP14) and MMP-2, play a critical role in degrading the basement membrane and the extracellular matrix (ECM), resulting in tumor cell dissemination and outgrowth of secondary cancers [3,4].