There were some statistically nonsignificant but noteworthy imbalances: the alternative therapy group had a greater percentage of patients requiring vasopressor support and a greater percentage of patients classed with severe protein C deficiency, with the lung as the primary site of infection, and the standard therapy group had a greater percentage of patients with renal dysfunction, with the abdomen as the primary site of infection, that were receiving insulin therapy, had a history of hypertension and a history of diabetes. This evidence concerns the gene INS and protein c deficiency.