PPARD and coronary artery disorder: Several previous studies have showed that the frequency of the rare allele (PPARD +294C) was significantly higher in Russian endurance-oriented athletes than in controls (18.3% vs. 12.1%, P < 0.0001) [42], in Tunisian CAD patients than in healthy volunteers (32.0% vs. 18.9%, P = 0.001) [34], and in Chinese CAD patients than in normal controls (30.8% vs. 19.5%, P < 0.05) [35].