Jean Grisouard discussed AMP-dependent kinase (AMPK) affecting the production of adipokines (e.g. TNF alpha, IL-6, leptin), which increase insulin resistance of adipocytes, whereas Metformin activating AMPK, reduced (pro-inflammatory) IL-6 and increased IL-1 receptor antagonist (which is anti-inflammatory), thereby potentially inhibiting IL-6 associated insulin-resistance and IL-1 induced tumour progression. This evidence concerns the gene IL6 and neoplasm.