Middle age subject had significantly higher NGAL values than those from DS children (167.51+82.28 SD ng/mL vs 75.06+48.73 SD ng/mL with p<0.01), differences were also found between elderly subjects and DS children (222.13+57.73 SD ng/mL vs 75.06+48.73 SD ng/mL with p<0.001). The gene discussed is LCN2; the disease is Dravet syndrome.