CD14 and breast angiosarcoma: Conversely, decreased sCD14 in late-stage BA, without a concomitant decrease of endotoxin in the liver and blood, may indicate a loss of protection against CD14-mediated LPS activation in Kupffer cells that propagates inflammatory reactions and fibrogenesis, resulting in irreversible liver injury and end-stage liver cirrhosis in patients with BA [10,16,35].