Several matching profiles (Results 2, 3, 5 and 9) implicate FoxO3 in hypoxia response: data from GDS2758 and GDS2760 compare MCF-7 breast cancer cells under hypoxic and normoxic conditions as well as with siRNAs targeting hypoxia-inducible factor 1 (HIF-1α) and HIF-2α. The gene discussed is EPAS1; the disease is breast cancer.