In the course of LYVE-1 staining, we noted that the LLC primary tumor was characterized by an absence of intra-tumoral LYVE1-positive lymphatic vessels in wildtype mice; and at the given primary tumor size (0.5 cm diameter), the density of sparse lymphatic vessels along the periphery of tumors from mutant versus wildtype littermates did not significantly differ (data not shown). The gene discussed is LYVE1; the disease is neoplasm.