Importantly, in examining CCL21 immunoreactivity in the lymph nodes of Ndst1f/fProx1+/CreERT2 mutants, while the signal localized to regions of tumor deposits, the relative expression of CCL21 in those regions was markedly reduced (Figure 7D, bottom panels) as compared to that in the lymph nodes of Cre negative control littermates (Figure 7D, upper panels), where tumor deposits were essentially fully decorated with CCL21. This evidence concerns the gene CCL21 and neoplasm.