In cancer, lymphatic remodeling and tumor invasion into the lymphatic conduit contribute directly to lymph node metastasis [6,7], and tumor-derived growth factors such as VEGF-C as well as chemokines produced by lymphatic vessels, such as CCL21/SLC (secondary lymphoid chemokine), have recently been implicated as key mediators of such events [8,9]. This evidence concerns the gene CCL21 and cancer.