Conditioned medium (CM) harvested from HS-targeted hLEC was applied to cultured LLC cells, and the cells were examined for the activation of two migration-related signaling intermediates: focal adhesion kinase (FAK) and glycogen synthase kinase 3β (GSK3β) (Figure 4A), both of which are activated in migrating tumor cells through phosphorylation. Here, PTK2 is linked to neoplasm.