As shown Additional file 25 Table S25, 43 enzymes in the valine, leucine, and isoleucine degradation pathway were down-regulated at 4 days post-infection, including acetyl-Coenzyme A acyltransferase family member (ACAA1, ACAA2 and ACAA1B), acyl-Coenzyme A dehydrogenase family member (ACAD8, ACAD10, ACADL, ACADM and ACADS), and aldehyde dehydrogenase family member (ALDH2, ALDH1A1, ALDH1A3, ALDH1A7, ALDH1B1, ALDH1B1, ALDH3A2 and ALDH6A1, ALDH7A1). The gene discussed is ACAD8; the disease is infection.