IRS1 and infection: We observed the mRNA level of IL-9 receptor (IL-2 R) and IL-4 receptor (IL-2R, IL-4R IL-13 R) are up-regulated and that downstream signaling protein, such as JAK2 JAK3, STAT1, STAT2, STAT3, IRS1, SOCS1 and SOCS3 showed up-regulation at 4 days post infection (Figure S2, Figure S8, Additional file 26 Table S26, and Additional file 27 Table S27).