The anti-inflammatory activity of glucocorticoids is mediated at least in part through physical interference of the glucocorticoid receptor complex with NF-κB DNA binding and increased synthesis of IκB [36], and there is some evidence of benefit from corticosteroids in the treatment of pneumococcal meningitis and perhaps also severe community-acquired pneumonia [37,38]. The gene discussed is NR3C1; the disease is pneumococcal meningitis.