ENG and diabetes mellitus: Limitations of our study are its cross-sectional design, which precludes longitudinal analysis between endoglin, cardiovascular risk factors and subclinical organ damage, and the selection of the study population, since sampling was performed consecutively with pragmatic and broad inclusion criteria, including patients with hypertension with a recent diagnosis or short course of hypertension, patients with diabetes and hyperlipidemia, and many patients receiving drug therapy.