Higher endoglin levels (above 5 ng/mL) were found in all patients with diabetes (odds ratio, 4.72) and in patients with hypertension and diabetes (odds ratio, 3.54) categorized as grade III and grade IV in the Keith-Wagener retinal changes classification, in both right and left eyes compared with patients with grades I and II (Figure 2). This evidence concerns the gene ENG and diabetes mellitus.