After multivariable adjustments for sex, BMI, systolic blood pressure, alcohol use, waist-hip ratio, diabetes, fasting glucose, total-HDL ratio, triglycerides, and adiposity biomarkers (leptin, adiponectin, ghrelin, IL-6), trends in rising bilirubin and falling GGT and albumin levels with increasing age remained significant with p-values for trend <0.05. The gene discussed is LEP; the disease is diabetes mellitus.