We tested the ability of the UAS:HRASV12 transgene to induce melanoma development following expression in somatic cells (i.e. in F0, after injection of the UAS:GFP-HRASV12 plasmid in the tg(mitfa:Gal4VP16; UAS:mCherry) line - named mitfa:Gal4 to simplify, or in the kita:Gal4 line, figure 7a). The gene discussed is MITF; the disease is melanoma.