CYP19A1 and cardiovascular disorder: For example, using data from the Framingham Heart Study, Peter et al found a single SNP in CYP19A1 in which the homozygous variant genotype was associated with higher diastolic blood pressure in women and lower pulse pressure in men.[1] Additionally, Ramirez-Lorca et al reported an association with CYP19A1 and blood pressure in women, but not men.[2] Therefore, our findings are the first of our knowledge in large cardiovascular disease populations to extend the previous sex-dependent effects of CYP19A1 on blood pressure to adverse outcomes.