To address these problems, we have applied metabolomics platforms to compare plasma metabolite patterns in weight-matched obese non-diabetic and T2DM African-American women, with or without an uncoupling protein 3 (UCP3) g/a missense polymorphism that results in substantial reductions in whole-body LCFA oxidation [27]. The gene discussed is UCP3; the disease is type 2 diabetes mellitus.