MYC and neoplasm: Moreover, much like MG132, celastrol inhibited the expression of various NF-κB target genes that are involved in multiple steps of tumor progression, including proliferation (CXCL1, c-Myc and Cyclin-D1), adhesion (ICAM-1), migration (CXCL1), invasion (MMP-9), and anti-apoptosis (BIRC2/4/5, Bcl-2 and Bcl-xL) (Table.