TMBIM6 and cancer: According to the ten introduced phenocopy criteria, a couple of compounds revealed liabilities through down-stream inhibition of PAI-1 transcription (BI1, BI5 & Ex2), at the regulation of off-target genes per se (BI1, Ex1 & Ex2), at the affection of inverse TGF-β signaling (Ex1 & Ex2), at the induction of cell death (Ex1 & Ex2), at acting as pro-inflammatory stimuli (Ex1 & Ex2) and as promoting cellular growth and induction of cancer pathways (BI3 & BI5) (Fig. 7).