Studies in an experimental model of cerebral malaria (ECM) caused by infection of C57BL/6 mice with P. berghei ANKA (PbA) have highlighted the important role played by various immune cells in disease pathogenesis, including CD4+ T cells, CD8+ T cells, conventional dendritic cells and Natural Killer (NK) cells [12], [13], [14], [15], [16], [17], [18]. The gene discussed is CD8A; the disease is infection.