Hypercholesterolemia, a high cholesterol diet and oxidative stress increase serum LDL levels resulting in increased risk for development of atherosclerosis.[9] Malondialdehyde a secondary product of lipid peroxidation is a major reactive aldehyde; higher levels can lead to peroxidation of biological membranes.[10] The antioxidant enzymes, mainly superoxide dismutase and catalase are first-line defensive enzymes against free radicals.[11] The qualitative analysis of Kumbhajatu indicated the presence of flavonoids and polyphenols. Here, CAT is linked to familial hypercholesterolemia.