An assessment of surgical stress using CRP and leukocyte count did not reveal any difference between children undergoing laparoscopy-assisted and posterior sagittal anorectoplasty for imperforate anus (QoE-C4).[25] Similarly, IL-6 and CRP levels did not differ significantly among children undergoing laparoscopy versus open appendectomy (QoE-C4).[26] Solitary studies on pull-through for Hirschsprung disease,[27] pyloromyotomy[28] and neonatal surgery[29] claimed a significantly lesser amount of stress markers in LS than in OS. This evidence concerns the gene IL6 and isolated anorectal malformation.