Similarly, increased SOD2 expression has been shown to be protective against ischemia reperfusion injury, xenobiotic cardiotoxicity, alcohol-induced liver injury, and diabetic cardiomyopathy (Chen et al. 1998; Shen et al. 2006; Wheeler et al. 2001; Yen et al. 1999). The gene discussed is SOD2; the disease is diabetic cardiomyopathy.