Concerning metabolic diseases (insulin resistance, metabolic syndrome, diabetes), Zn is considered important mainly because 1) it plays a major role in the stabilization of insulin hexamers and the pancreatic storage of the hormone [73] and 2) it is an efficient antioxidant [74], while oxidative stress is considered to be a main component in initiation and progression of insulin resistance and diabetes [7,75]. This evidence concerns the gene INS and diabetes mellitus.