However, the generation of a refined panel of antibodies able to detect both the frequent and the uncommon EGFR exon 19 deletions and exon 21 mutations as well as the resistance mutation T790 M in exon 20 could lead to the universal application of IHC for detecting EGFR mutations in NSCLC patients, as part of the routine IHC work-up of lung adenocarcinomas. The gene discussed is EGFR; the disease is lung adenocarcinoma.