Il-17 is the signature cytokine of the newly described T helper 17 (Th-17) cell population [58] and has been proposed as the founding member of a new subclass of proinflammatory cytokines involved in dengue, eliciting cytokines such as Il-6, Il-8, MCP-1, GRO-α and TNF-α [59]. This evidence concerns the gene CXCL1 and dengue disease.