GLP1R and hydrops fetalis: While observed effects of GLP-1R agonists on triglycerides and markers of cardiovascular risk may be related to weight loss, exploratory data in both animals and humans are consistent with direct effects of GLP-1R agonists on endothelial function, excretion of sodium, improvement in SBP, limitation of ischemia/reperfusion injury, and with improved myocardial function in HF.