EGFR-targeted drugs including tyrosine kinase inhibitors, such as erlotinib and gefitinib, are primarily used in lung cancer treatment producing significant clinical responses in 10% to 30% of all NSCLC patients [32,39,40] and currently used as first line therapy for lung cancers with EGFR mutations achieving about 70% response rates [41,42]. This evidence concerns the gene EGFR and lung cancer.