The results of the First-SIGNAL study comparing first-line cisplatinum/gemcitabine with gefitinib in the first-line treatment of 309 Asian never-smokers with advanced adenocarcinoma similarly showed improved 1-year PFS with gefitinib and a response rate of 84.6 versus 37.5% in EGFR mutation positive patients while extremely poor results were noted with gefitinib in wild-type patients [109]. Here, EGFR is linked to adenocarcinoma.