EGFR and non-small cell lung carcinoma: The recent IPASS study reported that Asian NSCLC patients containing wild-type EGFR had a shorter time to progression to EGFR TKIs as compared to the outcome of patients treated with classical chemotherapy and a very low response rate of 2% [41], suggesting that genetic wild-type of EGFR by and large confers primary resistance to EGFR TKIs.