Knockdown of Bim by small interfering RNA was able to attenuate apoptosis induced by EGFR TKIs, and addition of a BH3 mimetic enhanced gefitinib-induced apoptosis, suggesting that inducing Bim or use of BH3 mimetics may give rise to similar effects to inhibition of EGFR by promoting apoptosis and even overcoming EGFR TKI treatment resistance in lung cancer. This evidence concerns the gene EGFR and lung carcinoma.