On the contrary, Albertini and co-workers [16] assessed BNP value in 91 consecutive patients with type 2 diabetes mellitus, finding that BNP level was significantly higher in patients with LVDD, especially in case of untreated hypertension (87 ± 20 vs 13 ± 2, p < 0.0001); anyway, comparing the mean value of patient with normal LV function with those ones with LVDD, independently from the anti-hypertensive treatment, BNP was significantly higher in the latter group (p < 0.001). The gene discussed is NPPB; the disease is diabetes mellitus.