Mice treated with H19-DTA-P4-DTA exhibited a 61% (P < 0.001) reduction of the ex-vivo tumor volume (Figure 6A) and a 54% (P = 0.002) reduction of the ex-vivo tumor weight (Figure 6B) compared to H19-Luc-P4-Luc treated mice. The gene discussed is H19; the disease is neoplasm.