We have recently shown that signaling through ERα (using propylpyrazoletriol) dramatically decreased the frequency and severity of arthritis, and prevented osteoporosis development, in CIA in DBA/1 mice, whereas signaling through the other estrogen receptors (ERβ and GPR30) did not affect arthritic disease or bone loss [42]. The gene discussed is GPER1; the disease is arthritic joint disease.