PGM3 and Familial prostate cancer: However, considering that androgen metabolism is associated with the regulation of glycolytic enzymes and pentose-phosphate pathway [40], Pang's report that PGM3 converts glucose-1-phosphate to glucose-6-phosphate and mediates glycolysis as well as pentose phosphate shunt [38] suggests the possible involvement of PGM3 in prostate cancer metabolism.