In contrast, six proteins were significantly up-regulated, including melanoma-derived leucine zipper, extra-nuclear factor (AAH63595), activin A type I receptor precursor (NP_001096), smoothelin-A (AAF03563), KIAA0073 (BAA07555), hypothetical protein LOC57691 (NP_065982) and unnamed protein product (BAC03859) (Figure 3B and Table 1). Here, ACVR1 is linked to melanoma.