To verify the functional effects of ERK inhibition and Dox treatment on tumor cell killing, we injected stable shERK1, shERK2 or shControl HMESO MM cells subcutaneously into SCID mice, and treated various groups with Dox or saline at the tumor site as soon as tumors appeared (1 wk post cell inoculation, 3X weekly) for a 6 wk period. The gene discussed is MAPK1; the disease is neoplasm.