Exposure of both MM cell lines to the MEK1/2 inhibitor (U0126, 20 μM for 24 h) resulted in significantly altered levels of some of these genes (BCL2, cFOS, BRCA1, AR, ESR2, CYP3A4, PPARγ, BRCA2, ABCC3) (Table 1 and Additional Table 1), suggesting a role of ERK1 or 2 in their regulation. This evidence concerns the gene PPARG and Miyoshi myopathy.