CTLA4 and autoimmune disease: Although the molecular mechanisms through which the CT60 variant of CTLA4 exerts its effect in the development of autoimmune diseases are yet to be clarified, it should be emphasized that the CTLA4 CT60*G variant represents an 1.5-fold risk for the development of RA in the Hungarian sets of RF- and/or anti-CCP-seropositive rheumatoid arthritis patients.