The effect of TXR1–TSP1 mRNA expression on taxanes' cytotoxicity is independent of MDR phenotype (the ability of tumour cells to efflux taxanes through the upregulation of the ATP-dependent cell membrane glycoproteins) (Gottesman and Ling, 2006), as the overexpression of TXR1 did not affect the cellular accumulation of [3H]-labelled-paclitaxel in the resistant cells and did not reduce the sensitivity to other agents that are also expelled from tumour cells by the MDR (Lih et al, 2006). The gene discussed is PRR13; the disease is neoplasm.