THBS1 and neoplasm: The effect of TXR1–TSP1 mRNA expression on taxanes' cytotoxicity is independent of MDR phenotype (the ability of tumour cells to efflux taxanes through the upregulation of the ATP-dependent cell membrane glycoproteins) (Gottesman and Ling, 2006), as the overexpression of TXR1 did not affect the cellular accumulation of [3H]-labelled-paclitaxel in the resistant cells and did not reduce the sensitivity to other agents that are also expelled from tumour cells by the MDR (Lih et al, 2006).