This differential modulating effect of BRCA1 mRNA expression was also observed in tumour cells isolated from malignant effusions of NSCLC or gastric cancer patients (Wang et al, 2008), as well as in patients with ovarian cancer (Quinn et al, 2007), where high BRCA1 mRNA levels correlated negatively with cisplatin sensitivity and positively with docetaxel sensitivity. The gene discussed is BRCA1; the disease is ovarian cancer.