It has been suggested that for breast cancers that are less dependent on hormones, such as ER− and PR− breast cancers, the protective effect of phytochemicals present in fruit and vegetables on many cellular functions may be fully expressed, whereas for ER+ and PR+ cancers it can be overridden by hormonal factors (Olsen et al, 2003; Fung et al, 2005). The gene discussed is PGR; the disease is breast cancer.