Although at first view these findings appear surprising based on previous observations suggesting an association between POPs and the incidence of diabetes (Fierens et al. 2003; Lee et al. 2008), they are in agreement with a previous exploration in less obese men showing that the increase of organochlorine pollutants in human serum was positively associated with the decrease in insulin levels after diet-induced weight loss (Imbeault et al. 2002). Here, INS is linked to diabetes mellitus.