Assessing AD with a log(TG)/HDL-C ratio also incorporates occurrence of mutually reinforcing or diverging confounders affecting both fraction's components, such as insulin-sensitizers, certain LLDs, or ethanol intake (which often increase both terms), or diet, exercise or menopausal status, which affect numerator and denominator in opposite directions [12,17-20]. This evidence concerns the gene INS and Alzheimer disease.