Yet, such seemingly easy estimation is hampered by (i) lack of consensual cut-off values across gender, ethnicities and underlying conditions (ii) requirement for baseline lipid values prior to lipid-lowering drugs (LLD), (iii) a sine qua non association does not take into account imbalances between the severity of the two non-LDL lipid abnormalities, underestimating the magnitude of AD in groups with spontaneously low (Afro-Americans, sub-Saharan Africans) or with elevated TG levels prior to LLD or insulin [12-16]. This evidence concerns the gene INS and Alzheimer disease.