S100A2 and neoplasm: Some of the identified changes in gene methylation have been reported before: the hypermethylation of CDKN2A (p14ARF and p16ΙNK4a) has been implicated in carcinogenesis and tumor progression [10], whereas the hypomethylation of S100A2 [24] has been identified as a strong inducer of metastasis in vivo in non small cell lung cancer [25].