Thirteen genes were DE in GBM vs. control brain, consistent with their promoter methylation status (5 overexpressed genes with a hypomethylated promoter: B3GNT5, FABP7, ZNF217, BST2 and OAS1; 8 underexpressed genes with a hypermethylated promoter: SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14). The gene discussed is TSPYL5; the disease is glioblastoma.