IL-5 and CCL11 cooperate to generate an intestinal eosinophilia in a model of gastrointestinal allergy; here, initial eosinophil release from the bone marrow appears to be mediated by IL-5, whereas local production of CCL11 in the intestine mediates the recruitment from the blood to the intestine (33). The gene discussed is IL5; the disease is gastrointestinal allergy.