Ng et al. conducted a proof-of-concept experiment using Agilent exon-capture arrays and Illumina's Genome Analyzer to sequence the exomes of four unrelated individuals affected with the rare, dominantly inherited Freeman-Sheldon syndrome (FSS) and eight unaffected HapMap individuals, and unambiguously detected the previously identified gene MYH3 responsible for FSS [32]. This evidence concerns the gene MYH3 and Freeman-Sheldon syndrome.