In contrast, thrombospondin 1 (Thbs1), that is associated with tumour growth and angiogenesis, was downregulated and there was modulation of the cytoskeleton as evidenced by altered gene expression of laminin gamma 2 (Lamc2), filamin C gamma (Flnc), tubulin alpha 1a (Tuba1a) and actin gamma 2 (Actg2). Here, THBS1 is linked to neoplasm.