MDM2 and lung cancer: In the network of c-Abl and c-Src and similar to the observations described for the human lung cancer cell line A549, an induced expression of Mdm2 and Gadd45a was noted, as was an induction of the matrix metallopeptidases 3 and 13 (Mmp3 and Mmp13) that are involved in metastasis to support degradation of extracellular matrix proteins [41].