Interestingly, FGFR2 and FGFR3 expression was induced in all NSCLC cells that have been shown to be gefitinib sensitive (H322c, HCC827, HCC4006) and correlated with cells that co-express EGFR and EGF ligands (H322c, H1334, Calu3) or bear gain-of-function EGFR (HCC827, HCC4006, H1650) (Figure 1A). This evidence concerns the gene FGFR3 and non-small cell lung carcinoma.