TNF and colon carcinoma: Interestingly, in a colon carcinoma derived cell line, the application of conjugated primary bile salts (CPBS) reduced endotoxin permeability through differentiated confluent cells, and decreased the production of pro-inflammatory mediators, such as TNF-α, interleukin 6 (IL-6), interleukin 8 (IL-8) and interleukin 10 (IL-10).