The immunoreactivity of VEGFA, bFGF, TGF-β, MCP-1, TSP-1, TIMP-1, TIMP-2, and endostatin was observed mainly in the tumor and non-tumor hepatic cells, showing a predominant cytoplasmic staining, with the positive liver cells distributed in both the tumor tissue and surrounding liver. The gene discussed is COL18A1; the disease is neoplasm.