It has been confirmed that, the inflammasome pathway is distinct and independent from the type I IFN response that is triggered following DNA recognition in the cytoplasm [95].Thus, in addition to identifying a new pathway for host and microbial DNA recognition, the studies described might provide clues to the pathology of autoimmune diseases such as systemic lupus erythematosus (SLE) and chronic arthritis, which are often associated with autoreactive antibodies specific for self DNA and increased levels of IL-1β. This evidence concerns the gene IL1B and systemic lupus erythematosus.